STATUS OF EXOGENOUS ANTIOXIDANT, TOTAL ANTIOXIDANT CAPACITY AND OXIDATIVE STRESS IN SCA PATIENTS.

In India, haemoglobinopathies, especially sickle haemoglobin are the commonest genetic disorders in the tribal belt of Central and southern India. Madhya Pradesh and Chhattisgarh harbours the largest tribal population in India, which is about one fourth of the total tribal population of the county. The prevalence of sickle haemoglobin from various parts of Madhya Pradesh and Chhattisgarh varied from 15 to 30 percent. The study was carried out in Chhattisgarh Institute of Medical Sciences, Bilaspur (C.G.) Since the Eastern region of central India is prone to Sickle Cell Anemia.  Hence samples preferably collected from this area. The study was conducted on 90 human subjects. Out of which 30 were suffering from Sickle cell disease, 30 were Sickle Cell Trait and 30 were taken as control group. Haemoglobin, Malondialdehyde& antioxidants parameters were estimated. In subjects with homozygous sickle cell anemia, level of Plasma Malondialdehyde (MDA) were significantl (P<0.001) increased as compare to controls. The level of antioxidants vitamins C, E and TAC (P<0.001) decrease in group III as compare to controls. In group II the level of Vitamin C & Vitamin E decreased significantly (P<0.05) as compare to controls. Thus our study shows decreased Total antioxidant capacity , elevated plasma MDA and depleted antioxidant vitamins indicate increased oxidative stress in Sickle cell anemia patients. Therefore supplementation with antioxidants vitamin mayimprove some of the sickle cell symptoms.