Abstract ES3-2: Multidisciplinary management of breast cancer brain metastases

The management of breast cancer brain metastases requires a multi-disciplinary approach. Local treatment approaches including stereotactic radiosurgery (SRS) and surgery remain an integral component in the management of breast cancer patients. Systemic therapies with better penetration across the blood–brain barrier are currently being investigated. In this session, we will review the role of local therapies in the treatment of brain metastases and considerations on combining these different treatment modalities. We wish to exploit the novel interactions of SRS and systemic agents. We will discuss the evolving role of surgery, stereotactic radiosurgery and whole brain radiotherapy in the treatment of breast cancer brain metastases. We will review recent clinical trial data emphasizing the importance of preserving neurocognitive function in these patients and the general impact on current clinical practice. We will discuss issues regarding the optimal timing of systemic therapies in combination with local therapies and their impact on local control. Overall, there is a changing landscape in the treatment of breast cancer brain metastases with greater emphasis on preserving patients9 neurologic function. Clinical trial research continues to be a priority. Ultimately, our goal is a significant paradigm shift in the management of breast cancer brain metastases with the prevention of central nervous system (CNS) metastases. Citation Format: Tsien C. Multidisciplinary management of breast cancer brain metastases [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr ES3-2.