Effect of Toremifene on Endometrium and Neurocognitive Function in Patients with Breast Cancer Based on Resting State Functional MRI.

The paper used toremifene to study the characteristics of hemodynamic changes before and after neoadjuvant chemotherapy in breast cancer by using resting state functional MRI quantitative method, and to analyse the effect of toremifene on the recent quality of life of advanced breast cancer. Methods: A total of 100 patients who received endocrine therapy after breast cancer surgery in our hospital from January 2016 to January 2019 were collected as the research objects. They were randomly divided into observation group and control group, with 50 cases in each group. The observation group was treated with tamoxifen Combined toremifene treatment, the control group was treated with toremifene. Before and after chemotherapy, the same scheme was used to perform breast dynamic MRI enhancement scan, using 1.5T superconducting MRI imager, 3ml/s bolus injection of adiphenine meglumine 0.2mmol/kg; semi-quantitative blood flow measurement was completed on the workstation, and before and after chemotherapy Compare the results. At the same time, analyse the patient's recent quality of life, progesterone, estrogenic levels, social function, physical function, mental function, and material function. The mean values of the early enhancement parameters Efirst, Vfirst, Ee and Ve before chemotherapy were greater than the residual lesions after chemotherapy (P<0.5). The semi-quantitative study of resting brain function before and after breast cancer neoadjuvant chemotherapy showed that the hemodynamic of the residual lesions were significantly reduced, and the blood flow rate was significantly reduced. Compared with the clinical effect of tamoxifen in the treatment of breast cancer after surgery, tamoxifen combined with toremifene has more advantages in improving the recent quality of life, progesterone levels, and reducing estrogenic levels, and it has no disadvantages to the endometrium influences.