Az anaemia perniciosa terápiájának története | History of the therapy of pernicious anemia

A kivereztetett kiserleti allatok verregeneraciojat Whipple a nyers maj, Jeney es Jobling pedig a maj vizes kivonatanak adagolasaval tudta fokozni. A majetetes terapias hatekonysagat Minot es Murphy 45, anaemia perniciosas betegen 1926-ban igazoltak. Whipple, Minot es Murphy a majterapia sikeres alkalmazasaert 1934-ben Nobel-dijban reszesult. A B 12 -vitaminnak elnevezett hatoanyagot 1948-ban sikerult majbol kivonni. Lucy Wills ugyanezen evekben alultaplalt, terhes asszonyok anaemiajat kedvezően tudta befolyasolni elesztőkivonattal, ami a folsav felfedezesehez vezetett. Mindket gyogyszer hatasmodjanak tanulmanyozasa jelentősen gazdagitotta patofiziologiai ismereteinket, tovabba ujabb terapias alkalmazasokat tart fel. Orv. Hetil., 2013, 154, 1754–1758. | Increased blood cell regeneration in exsanguinated experimental animals treated either with liver or with aqueous liver extracts was reported by Whipple and by Jeney and Jobling, respectively. These findings stimulated Minot and Murphy to provide evidence for the efficacy of liver against anaemia in clinical studies. After oral administration of liver (45–50 g per day) for 45 patients with anaemia perniciosa improvement of the hematological status was demonstrated. Consequently, for proving the therapeutic value of liver therapy Whipple, Minot and Murphy received Nobel price in 1934. The isolation of the antianemic factor from the liver has been succeded in 1948 and designated as vitamin B 12 . At the same time Lucy Wills applied yeast for the treatment of pregnant women with anemia related to undernourisment. The conclusions of this study inspired the discovery of folate. The detailed investigation of the mode of action of vitamin B 12 and folate enriched our knowledge in the area of pathophysiology and extended the clinical application of these two drugs. Orv. Hetil., 154 (44), 1754–1758.