Circulating Microparticles from Crohn’s Disease Patients Cause Endothelial and Vascular Dysfunctions

Background Microparticles (MPs) are small vesicles released during cell activation or apoptosis. They are involved in coagulation, inflammation and vascular dysfunction in several diseases. We characterized circulating MPs from Crohn’s Disease (CD) patients and evaluated their effects on endothelial function and vascular reactivity after in vivo injection into mice.