Association of Killer cell immunoglobulin-like receptors (KIRs) polymorphisms and advanced cancer in a Caucasian population.

e12563 Background: Killer cell immunoglobulin-like receptors (KIRs) are a family of activating and inhibitory receptors expressed on natural killer (NK) cells and T cells, the genes of which show extreme polymorphism. Previous studies have shown associations between KIRs polymorphisms, their ligands and either protection or susceptibility to breast cancer. However, either the association to other solids tumor or advanced cancers remain unknown. Our aim was to investigate the prevalence of KIRs gene polymorphisms in 3 different advanced cancers: colorectal, breast and head and neck in a Caucasian population. Methods: 75 patients on monoclonal antibody treatment (Trastuzumab or Cetuximab) were selected (28 colorectal, 30 breast and 17 head and neck). KIR genotyping was performed using sequence-specific primers able to detect the presence of 16 different KIR genes (2DL1, 2DL2, 2DL3, 2DL4, 2DL5, 3DL1, 3DL2, 3DL3, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 3DS1, 2DP1 and 3DP1). Results: Our results showed that the KIRs 2DL...