Efficacy of the Travoprost/Timolol fixed Combination Versus the Concomitant use of Travoprost 0.004% and Timolol 0.1% Gel Formulation

In a study conducted by Kozobolis et al. [1] the Intraocular Pressure Lowering (IOP) efficacy of the travoprost 0.004%/ Timolol 0.5% Fixed Combination (TTFC group) was compared to that of the concomitant use of each of the constituents of the fixed combination (Travopost 0.004% and timolol gel 0.1%, Trav+Geltim group) in patients with ocular hypertension and primary open angle glaucoma. The TTFC was administered at 21:00 and in the Trav+Geltim group, the prostaglandin was instilled at 21:00 and the timolol gel 0.1% at 08:00. The patients who were on other glaucoma drops before the study were asked to stop the drops for a wash out period of 14-30 days before participating in the study. The IOP was measured at 4 time points during the day: At 09:00, 12:00, 15:00, and 18:00.