Establishment of patient-derived renal cell carcinoma (RCC) models based on orthotopic xenografts (PDX) and cancer stem cell (CSC) isolation to provide prognostic and predictive information.

Simona di Martino,Gabriele De Luca,Ludovica Grassi,Giulia Federici,Laura De Salvo,Anna Laura Di Pace,Antonio Addario,Giovanni Muto,Manuela Costantini,Mauro Biffoni,Michele Signore,Isabella Sperduti,Steno Sentinelli,Michele Milella,Francesco Cognetti,Michele Gallucci,Ruggero De Maria,Désirée Bonci

Establishment of patient-derived renal cell carcinoma (RCC) models based on orthotopic xenografts (PDX) and cancer stem cell (CSC) isolation to provide prognostic and predictive information.

2017

Simona di Martino
Gabriele De Luca
Ludovica Grassi
Giulia Federici
Laura De Salvo
Anna Laura Di Pace
Antonio Addario
Giovanni Muto
Manuela Costantini
Mauro Biffoni
Michele Signore
Isabella Sperduti
Steno Sentinelli
Michele Milella
Francesco Cognetti
Michele Gallucci
Ruggero De Maria
Désirée Bonci

e16055Background: The introduction of VEGF/VEGFR- and mTOR, and immune checkpoint-targeted agents has radically changed metastatic RCC treatment; however, predictive biomarkers are still lacking an...

Keywords:

Renal cell carcinoma
Cancer stem cell
Pathology
Cancer research
Medicine
predictive biomarker
Immune system
VEGF receptors
PI3K/AKT/mTOR pathway

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