Treatment with a proton pump inhibitor improves glycaemic control in Psammomys obesus, a model of type 2 diabetes

Thora B. Bodvarsdottir,K. D. Hove,Carsten F. Gotfredsen,L. Pridal,A. Vaag,Allan E. Karlsen,Jacob S. Petersen

Treatment with a proton pump inhibitor improves glycaemic control in Psammomys obesus, a model of type 2 diabetes

2010

Thora B. Bodvarsdottir
K. D. Hove
Carsten F. Gotfredsen
L. Pridal
A. Vaag
Allan E. Karlsen
Jacob S. Petersen

Aims/hypothesis Gastrin has been implicated in islet growth/neogenesis, and proton pump inhibitors (PPIs) have been shown to increase endogenous gastrin levels in animals and humans. Therefore, we investigated the effect of PPIs in a model of type 2 diabetes, Psammomys obesus.

Keywords:

Insulin
Proton pump
Gastrin
Psammomys
Diabetes mellitus
Endocrinology
Type 2 diabetes
Islet
Biology
Neogenesis
Internal medicine

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