753 Isolated pelvic perfusion for treatment of non-resectable pelvic recurrences

Twenty patients affected by non-resectable pelvic recurrence of primary pelvic malignant neoplasm were treated by Isolated Pelvic Perfusion. All patients were before treated by surgery and/or systemic chemotherapy and/or radiotherapy for their primary pelvic tumor. Patients underwent to laparotomy and IPP for 90 minutes at 40°C with high doses of drugs. Ten cases of rectal adenocarcinoma have been treated with Mitomycin-C (MM) and 5-FU and Mitoxantrane, in six cases of cervical carcinoma we employed a combination of MMC and Cis-Platin. One case of spindle cell anal carcinoma was treated with MMC, one case of penis carcinoma with Methotrexate, one case of endometrial adenocarcinoma with Cis-Platinum and finally one case of melanoma of the vulva with L-PAM. Three CR and seven PR were observed; three patients had a stable disease and two other patients were no responders and died for progression in few months. One patient is lost to follow-up and four patients recently treated are not evaluable. The advantage in responsiveness and the low incidence of complications suggest a possible indication of this technique as a first approach for pelvic recurrences. This work has been supported by AIRC, contribution 1994.