Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model

The aim of this study was to assess the effect of oral administration of Hydroalcoholic Extract of Green Propolis (HEGP) on dermal carcinogenesis in rodent model. For the biological assay, we used 36 mice, assigned into 6 groups (n=6): CTR (treated with 100 mg/kg HEGP and no tumor induction), TUM (treated with water and tumor induction), GP10 (treated with 10 mg/kg HEGP and tumor induction), GP50 (treated with 50 mg/kg HEGP and tumor induction) and GP100 (treated with 100 mg/kg HEGP and tumor induction). Cancer induction was performed in the back of the mice by topical application of DMBA. After 16 weeks, mice were euthanized and their backs were submitted to post-mortem histological analysis. The mean number of lesions developed in TUM (4.14±0.89) was significantly higher than in GP10 (2.05±1.02), GP50 (1.8±1.92) and GP100 (2.5±1.73) (p El objetivo de este estudio fue evaluar el efecto de la administracion oral de extracto hidroalcoholico del propoleos verde (HEGP) sobre la carcinogenesis dermica en modelo de roedores. Para el ensayo biologico, se utilizaron 36 ratones asignados en 6 grupos (n = 6): CTR (tratado con 100 mg/kg HEGP y sin induccion de tumores), TUM (tratada con agua e induccion de tumores), GP10 (tratado con 10 mg/kg HEGP e induccion de tumores), GP50 (tratado con 50 mg/kg HEGP e induccion de tumores) y GP100 (tratado con 100 mg/kg HEGP e induccion de tumores). La induccion de cancer se llevo a cabo en la region dorsal de los ratones por aplicacion topica de DMBA. Despues de 16 semanas, los ratones fueron sacrificados y sus dorsos fueron sometidos a analisis histologico post-mortem. El numero medio de lesiones desarrolladas en TUM (4,14±0,89) fue significativamente mayor que GP10 (2,05±1,02), GP50 (1,8±1,92) y gp100 (2,5±1,73) (p