Influence Of Injection Sclerotherapy Of Oesophageal Varices In Liver Cirrhosis On The Haemostatic System

SummaryPlatelet counts, coagulation and fibrinolysis tests were done before, 10 min. 1, 3 and 24 hr after the performance of 24 sessions of injection Serotherapy with Polidocanol 1 % of oesophageal varices in 16 patients with liver cirrhosis. Thrombocytopenia was often present no significant changes occurred after sclerotherapy. The APTT and PT values did not change. The levels of F II. F V. F VII-X, F VIII F IX. and F X remained in the same range. Also the fibrinogen and plasminogen values did not change after the selerotherapy session. A rise in the scrum fibrin/fibrinogen degradation Products was not found, levels of antithrombin protein C, x antiplasmin and t-PA antigen femaincd stable. The absence of any change in the clotting parameters measured is in accordance with the clinical safety of the injection sclerotherapy of aesophageal varices in patients with liver cirrhosis.