Low utilization of pre-implantation genetic diagnosis in women with BRCA mutations.

e13619Background: Identification of a BRCA mutation can profoundly impact family planning for women of reproductive age. Assisted reproductive technology (ART), including pre-implantation genetic diagnosis (PGD), provide chances to prevent BRCA carrier status in offspring. The patient (pt) may receive genetic information on embryos with option to select against BRCA mutations for implantation. Studies have found that about 60% of BRCA mutation carriers feel PGD should be offered, but only 35% would undergo PGD. We sought to evaluate the rates of counseling and utilization of PGD in pts with BRCA mutations at a high volume center for ART. Methods: We performed a retrospective chart review of reproductive age women with a BRCA mutation at a single institution from 8/2012 - 9/2017. Exclusion criteria were: history of risk-reducing salpingo-oophorectomy (RRSO), known ovarian cancer, or age ≥ 50 years. Results: We identified 343 pts for analysis, of whom 156 (45%) were counseled about reproductive options by a...