Carbamazepine induced Toxic Epidermal Necrolysis.

Toxic epidermal necrolysis is a potentially life-threatening situation for skin that is frequently induced by drugs. The mucocutaneous reaction is characterized by bullous detachment of the epidermis and mucous membranes. Here we are reporting a case of toxic epidermal necrolysis in a 25 year old female Epileptic patient after receiving the Carbamazepine. On the second day of the Carbamazepine patient developed facial puffiness and macula papular rash with flaccid bullae present over the face, lips, upper back which spreads gradually all over the body.There was burning sensation,watering and pain in both eyes, mating of eye lashes also present.She is diagnosed as toxic epidermal necrolysis. The Clinical impression was TEN induced by Carbamazepine. She was treated with injection Dexamethasone, Pheniramine, topical antibiotics and corticosteroids.The outcomes of the treatment includes withdrawl of inducing agent and early diagnosis and treatment is needed.