Understanding the nature of face processing in early autism: A prospective study
2020
Dimensional approaches to psychopathology interrogate the core neurocognitive
domains interacting at the individual level to shape diagnostic symptoms. Embedding
this approach in prospective longitudinal studies could transform our understanding of
the mechanisms underlying neurodevelopmental disorders. Such designs require us to
move beyond traditional group comparisons and determine which domain-specific
atypicalities apply at the level of the individual, and whether they vary across distinct
phenotypic subgroups. As a proof of principle, this study examines how the domain of
face processing contributes to a clinical diagnosis of Autism Spectrum Disorder (ASD).
We used an event-related potentials (ERPs) task in a cohort of 8-month-old infants with
(n=148) and without (n=68) an older sibling with ASD, and combined traditional casecontrol comparisons with machine-learning techniques like supervised classification for
prediction of clinical outcome at 36 months and Bayesian hierarchical clustering for
stratification into subgroups. Our findings converge to indicate that a broad profile of
alterations in the time-course of neural processing of faces is an early predictor of later
ASD diagnosis. Furthermore, we identified two brain response-defined subgroups in
ASD that showed distinct alterations in different aspects of face processing compared
to siblings without ASD diagnosis, suggesting that individual differences between
infants contribute to the diffuse pattern of alterations predictive of ASD in the first year
of life. This study shows that moving from group-level comparisons to pattern
recognition and stratification can help to understand and reduce heterogeneity in
clinical cohorts, and improve our understanding of the mechanisms that lead to later
neurodevelopmental outcomes.
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