Seroprevalence of Anti-Helicobacter pylori and Anti-CagA IgG Antibodies in Iranian Dyspeptic Patients
2018
Background: Helicobacter pylori, a worldwide infection, is associated with several infectious
diseases including gastric ulcer, peptic ulcer, and gastric cancer resulting from the cytotoxinassociated
gene A (CagA). The purpose of this study was to evaluate the seroprevalence of
anti-H. pylori and anti-CagA IgG antibodies in Iranian dyspeptic patients.
Methods: In this prospective epidemiological survey, a total of 659 patients were evaluated for
the presence of general anti-H. pylori IgG, and then for anti-CagA IgG by two commercial ELISA
kits.
Results: The prevalence of general anti-H. pylori IgG was 58.1% (383 of 659 patients) which
increased progressively with age (P<0.05) and was not significantly influenced by the sex
(P=0.08). The prevalence of anti-CagA IgG antibody in seropositive and seronegative patients
for general H. pylori IgG was 52.9% (37 of 70) and 61.9% (13 of 21), respectively.
Conclusion: This is the first report on the high prevalence of anti-CagA IgG in both seropositive
and seronegative patients for general IgG, indicating the importance of this antibody in diagnosis
of H. pylori positive patients after seroconversion of the general IgG.
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