[Genetic HLA markers associated with pulmonary tuberculosis in the Barum-Khemchiksky District, Republic of Tyva].

Abstract Detection of the genetic markers determining a predisposition to pulmonary tuberculosis is a necessary condition for the warranted formation of risk groups in the populations. On this basis, the authors used immunogenetic studies to examine 60 patients with pulmonary tuberculosis and 96 healthy individuals of Tuvinian nationality, who lived in the Barum-Khemchiksky District, Republic of Tyva. The microlymphocytotoxic test was used to determine class I HLA antigens and polymerase chain reaction was employed to reveal the specificity of class II HLA-DRB1 gene. The study revealed a positive association of HLA-B27 antigen and the specificities of HLA-DRB1 13(6) HLA-DRB1 14(6) with tuberculosis, which permits tuberculosis risk groups to be formed, by taking into account the immunogenetic data obtained in this district of the Republic of Tyva.