Intravenous Acetylcholine Therapy in Neurosis: A Controlled Clinical Trial

1. The literature reporting the use of acetylcholine in the treatment of psychiatric conditions is reviewed. 2. The design of a controlled study, to test the efficacy of the recently introduced modified method for the treatment of neuroses is described. 3. Results of treatment in 55 cases are reported. 4. Evidence that two groups of 18 cases are comparable is presented. 5. Results of the treatment of one of these groups with intravenous acetylcholine and the other with intravenous distilled water under identical conditions are reported. 6. On the evidence that almost identical results were obtained in the two groups, and that results in the control group compare with those previously obtained by the authors and others when using acetylcholine, it is suggested that acetylcholine has no specific therapeutic effect in the treatment of neurosis.