Mechanism of brain dysfunction on children with nocturnal enuresis by the technique of fractional amplitude of low frequency fluctuation of functional magnetic resonance imaging

Objective To research the pathological mechanism of the performance of enuresis and the brain dysfunction of attention and memory deficit of nocturnal enuresis (NE) by fractional amplitude of low frequency fluctuation (fALFF) of resting-state functional magnetic resonance imaging (rs-fMRI). Methods The approach of fALFF was used to analyze on 18 NE children and normal children, both of whom had been examined by rs-fMRI scans. Then the differences of fALFF were compared by two sample t-test. Results The brain regions which had obvious differences of fALFF between two groups were cerebellum(MNI: -12, -57, -33), left frontal lobe(-21, 42, -9), right temporal lobe(45, -12, -12) and occipital lobe(-18, -90, 39). And the group of NE was lower than normal children on all the four regions. The decrease of the value of fALFF on cerebellum made the dysfunction of timing of controlling urinary. And the weaken of the activity of left frontal lobe made the inhibition of attentional perform. The decrease of the value of fALFF on right temporal lobe and occipital lobe was probably related to memory. Conclusion The performance of NE is associated with the impairment of cerebellum.The dysfunction of cerebellum and left frontal lobe makes attention decrease and the deficit of memory is probably related to the impairment of right temporal lobe and occipital lobe. Key words: Resting-state functional magnetic resonance imaging; Nocturnal enuresis; Fractional amplitude of low frequency fluctuation