Delayed post-ischaemic administration of xenon reduces brain damage in a rat model of global ischaemia

Cerebral ischaemia is among the leading causes of death, disability and economic expense in the world. Xenon has been shown to be neuroprotective both in vivo and in vitro, predominantly when administered as a preconditioning agent. We have used a rat model of global ischaemia to investigate whether xenon-induced neuroprotection is observed following an ischaemic insult.