Asociación del polimorfismo 4G/5G del gen PAI-1 con el perfil de lípidos en pacientes con artritis reumatoide, osteoartritis y controles clínicamente sanos

The 4G/5G polymorphism of the plasminogen activator in- hibitor type 1 (PAI-1) affects the plasmatic concentration of the protein. Besides, in vitro studies demonstrated that triglycerides, very low density lipoproteins-cholesterol (VLDL-c), insulin and glucose increase the gene expression. Objective: To analyze the genetic and allele frequency of the 4G/5G polymorphism of the PAI-1 and its association with the lipid profile in patients with rheumatoid arthritis (RA), osteoarthritis (OA) and clinical healthy controls (HC). Mate- rial and methods: Cross-sectional study. The 4G/5G poly- morphism of PAI-1, was analyzed for PCR-RFLP's (polymer- ase chain reaction- restriction fragment length polymorphisms) using the restriction enzyme Bsl I. The sta- tistical analysis fulfilled with the SPSS 10.0 and Epi Info 2000. Results: The population studied was in Hardy-Weinberg's