Autocrine VEGF and IL-8 Promote Migration via Src/Vav2/Rac1/PAK1 Signaling in Human Umbilical Vein Endothelial Cells

Li Ju,Zhiwen Zhou,Bo Jiang,Yue Lou,Xirong Guo

Autocrine VEGF and IL-8 Promote Migration via Src/Vav2/Rac1/PAK1 Signaling in Human Umbilical Vein Endothelial Cells

2017

Li Ju
Zhiwen Zhou
Bo Jiang
Yue Lou
Xirong Guo

Background/Aims: Pro-angiogenic factors VEGF and IL-8 play a major role in modulating the migratory potential of endothelial cells. The goal of this study was to

Keywords:

Autocrine signalling
PAK1
Proto-oncogene tyrosine-protein kinase Src
RAC1
VAV2
Interleukin 8
Biology
Cancer research
Umbilical vein
VEGF receptors
Vascular endothelial growth factor A
Autocrine Communication

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