Secretion of prorenin by a virilizing ovarian tumor

Abstract A-53-year-old normotensive, normokalemic female presented with a 6-month history of virilization. Estradiol, LH, FSH, urinary-free cortisol, and DHEA-S levels were normal. Pelvic ultrasound and computerized tomography were also within normal limits. Her serum testosterone (551 ng/dl; nl, 20–70) and plasma prorenin (124 ng A 1 /ml/hr; nl,