Differentiation of a single melanocytic lesion of the esophagus: primary malignant melanoma of the esophagus or esophageal metastatic melanoma.

A single melanocytic lesion of the esophagus should be differentiated from a primary malignant melanoma of the esophagus (PMME) or an esophageal metastatic melanoma (MME). This paper reviews the current knowledge about these entities and how to differentiate between them. Melanocytosis as a precursor of PMME is discussed as well.