PUL01.01 Ground Glass Opacity: What’s in a Name?

Background: Ground glass opacity (GGO), consists of hazy opacity not obscuring the underlying bronchial structures or pulmonary vessels the underlying pathology varies from benign conditions (pulmonary edema, infections - including COVID-19, cytomegalovirus, Pneumocystis jirovecii, etc), noninfectious interstitial lung diseases and adenocarcinomas Methods: Following IRB approval our electronic files from January-July 2020 were searched for sampled GGO in comparison with other types of lung lesions found in our patients Tissue was collected using tip-tracked guided procedures We compared association of GGO with adenocarcinoma of the lung with lepidic spread (ADCC-L) (Image 1, 2) Results: 122 pathology cases (male=64) were identified: 40 benign and 82 malignant diagnoses There were 39 cases of ADCC-L (median [interquartile range] age: 63 [60-71]) and 83 cases with various other lesions (age: 62 [57-67]) GGO were reported in 17 ADCC-L cases and 13 of the other cases The Fisher exact test statistic demonstrated a statistically significant association between ADCC-L and GGO in our overall (n=122, p=0 0014*) and female (n=58, p=0 0151*) cohorts Conclusion: 1 Tip-tracked guided procedures obtain diagnostic tissue from these challenging to sample lesions 2 GGO statistically significant association with AADCC-L in our patient population indicates necessary appropriate follow-up for appropriate patient management [Formula presented] [Formula presented]