Expression of tight-junction-associated proteins in human gastric cancer: downregulation of claudin-4 correlates with tumor aggressiveness and survival

Satoshi Ohtani,Masanori Terashima,Jun Satoh,Nobutoshi Soeta,Zenichiroh Saze,Seigo Kashimura,Fumihiko Ohsuka,Yutaka Hoshino,Michihiko Kogure,Mitsukazu Gotoh

Expression of tight-junction-associated proteins in human gastric cancer: downregulation of claudin-4 correlates with tumor aggressiveness and survival

2009

Satoshi Ohtani
Masanori Terashima
Jun Satoh
Nobutoshi Soeta
Zenichiroh Saze
Seigo Kashimura
Fumihiko Ohsuka
Yutaka Hoshino
Michihiko Kogure
Mitsukazu Gotoh

Background Claudin, occludin, and zonula occludens (ZO)-1 are known as tight-junction-associated proteins. The aim of this study was to examine the expression of these proteins in gastric carcinoma.

Keywords:

Medicine
Pathology
Carcinoma
Cancer
Occludin
Tight junction
Downregulation and upregulation
Metastasis
Claudin
Immunohistochemistry
gastric carcinoma
Surgical oncology

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