EPS2.07 How did the COVID-19 lockdown influence the nutritional status and body composition of cystic fibrosis patients in Poland?

Background: The global COVID-19 pandemic has changed daily life, due to restrictions affecting day-to-day functioning. The strict lockdown changed habits of cystic fibrosis (CF) patients as well. The aim of our study was to evaluate the impact of the one-month strict spring lockdown in Poland on the nutritional status and body composition of CF paediatric patients. Methods: All CF patients between 8 and 18 years old who had both in- and outpatient visits with completed data at the Cystic Fibrosis Centre in Warsaw were included in the study. BMI z-scores (CDC calculator), as well as the fat free mass index (FFMI) and the fat mass index (FMI) were calculated according to the following formulas: FFMI = FFM/height2, FMI = FM/height2. The strict lockdown (SL) in Poland was between 16.03.20 and 20.04.20. The measures were evaluated on average: 3 months before SL (M1);3 months after SL (M2), and 3 months after M2 (M3). Results: 101 CF subjects (51% female), with a mean age of 11.53 ± 3.29 years were assessed. 48% of them were heterozygotes F508del and 80% had pancreatic insufficiency. The highest significant increase in values of BMI z-score and FMI was observed after SL (M2) with decrease in M3 (F = 7.18;p = 0.001;F = 4.71;p = 0.01, respectively). FFMI increased significantly and continually from M1 to M3 (F = 14.17;p < 0.001). The mean values for BMI z-score, FMI and FFMI were, respectively, as follows: M1: [–0.20 ± 0.86;4.00 ± 1.51;13.81 ± 1.86];M2: [–0.05 ± 0.82;4.19 ± 1.54;14.05 ± 1.91];M3: [–0.14 ± 0.84;4.07 ± 1.46;14.17 ± 1.91]. The mean 3 months differences between measures [M2 vs M1] and [M3 vs M2] were negative for BMI z-score [–0.17 ± 0.49;p = 0.005];FMI [–0.21 ± 0.77;p = 0.006];FFMI [–0.07 ± 1.15;p = 0.56]. Conclusion: CF paediatric patients improved nutritional status after strict lockdown with increase both FMI and FFMI, nevertheless a decline with time was observed in BMI z-scores and FMI, but not for FFMI.