XPO1-dependent nuclear export is a druggable vulnerability in KRAS -mutant lung cancer

Jimi Kim,Elizabeth McMillan,Hyun Seok Kim,Niranjan Venkateswaran,Gurbani Makkar,Aime Rodriguez-Canales,Pamela Villalobos,Jasper E. Neggers,Saurabh Mendiratta,Shuguang Wei,Yosef Landesman,William Senapedis,Erkan Baloglu,Chi Wan B. Chow,Robin E. Frink,Boning Gao,Michael G. Roth,John D. Minna,Dirk Daelemans,Ignacio Ivan Wistuba,Bruce A. Posner,Pier Paolo Scaglioni,Michael A. White

XPO1-dependent nuclear export is a druggable vulnerability in KRAS -mutant lung cancer

2016

A multi-genomic approach identifies the addiction of KRAS-mutant lung cancer cells to XPO1-dependent nuclear export, offering a new therapeutic opportunity.

Keywords:

Addiction
Cancer research
KRAS
Druggability
Mutant
XPO1
Genetics
Lung cancer
Nuclear export signal
Vulnerability
Biology
RNA interference
YAP1
Cell nucleus
Bioinformatics
Nuclear protein

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