Nanosuspension: a novel approach to enhance solubility of poorly water soluble drugs- A review

Solubility is the crucial factor for drug effectiveness, independence of the route of administration. Large proportion of newly discovered drugs are water insoluble & therefore poorly bioavailable contributing to desert development effort. Nanosuspensions have emerged as a promising strategy for the efficicent delivery of hydrophilic drugs because of their versatile features &unique advantages. The reduction of drug particles into submicron range leads to a significant increase in dissolution rate & therefore enhances bioavailability. Nanosuspension contain submicron colloidal dispersion of the pharmaceutical active ingredient particles in a liquid phase stabilised by surfactant. Nanosuspensions can be delivered by oral & non-oral route of administration. Study is focused on various methods of preparation with advantages & disadvantages, characterization properties, applications.