Antidiabetic effects of polysaccharide from azuki bean (Vigna angularis) in type 2 diabetic rats via insulin/PI3K/AKT signaling pathway

Abstract The prevalence of type 2 diabetes mellitus (T2DM) is increasing year by year worldwide, which threatens human health severely. This study aimed to investigate the antidiabetic effects and the potential mechanism of polysaccharide from azuki bean (ABP) in high fat diet and STZ-induced type 2 diabetic rats. Results showed that oral administration of ABP could significantly reduce weight loss and fasting blood glucose (FBG) levels and concentration of serum triglyceride (TG) compared with those of the untreated diabetic rats (p