Construction of All-Carbon Quaternary Stereocentersvia Sequential Photoactivation/Isothiourea Catalysis
2019
Highly enantioselective [4 + 2] cyclizations of azadienes with in situ generated ketenes were developed through sequential visible-light photoactivation/isothiourea catalysis, which offers a novel approach for the creation of all-carbon quaternary stereocenters through disubstituted C1-ammonium enolates. The visible-light-induced sustained release of reactive ketene species through Wolff rearrangement of α-diazoketones is crucial for achieving high levels of chemical efficiency and stereoinduction.
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