The effect of comorbidity of restless legs syndrome and migraine on sleep and mood: an integration of multicenter data

We evaluated the impact of migraine and restless legs syndrome (RLS) comorbidity on sleep and mood using two different clinical settings (Study 1, 33 RLS patients from a multicenter study; Study 2, 262 active migraine patients from a single-center study). Although the presence of migraine in RLS patients was not correlated with sleep problems or depressive symptoms (Study 1), the presence of RLS in active migraine patients was associated with poor sleep quality, daytime sleepiness and depressive symptoms (Study 2). RLS is an important comorbidity associated with active migraine; however, the clinical setting in particular may influence the RLS–migraine association.