Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

David T. W. Jones,Barbara Hutter,Natalie Jäger,Andrey Korshunov,Marcel Kool,Hans-Jörg Warnatz,Thomas Zichner,Sally R. Lambert,Marina Ryzhova,Dong Anh Khuong-Quang,Adam M. Fontebasso,Adrian M. Stütz,Sonja Hutter,Marc Zuckermann,Dominik Sturm,Jan Gronych,Bärbel Lasitschka,Sabine Schmidt,Huriye Seker-Cin,Hendrik Witt,Marc Sultan,Meryem Ralser,Paul A. Northcott,Volker Hovestadt,Sebastian Bender,Elke Pfaff,Sebastian Stark,Damien Faury,Jeremy Schwartzentruber,Jacek Majewski,Ursula D. Weber,Marc Zapatka,Benjamin Raeder,Matthias Schlesner,Catherine L. Worth,Cynthia C. Bartholomae,Christof von Kalle,Charles D. Imbusch,S. Radomski,Chris Lawerenz,Peter van Sluis,Jan Koster,Richard Volckmann,Rogier Versteeg,Hans Lehrach,Camelia-Maria Monoranu,Beate Winkler,Andreas Unterberg,Christel Herold Mende,Till Milde,Andreas E. Kulozik,Martin Ebinger,Martin U. Schuhmann,Yoon-Jae Cho,Scott L. Pomeroy,Andreas von Deimling,Olaf Witt,Michael D. Taylor,Stephan Wolf,Matthias A. Karajannis,Charles G. Eberhart,Wolfram Scheurlen,Martin Hasselblatt,Keith L. Ligon,Mark W. Kieran,Jan O. Korbel,Marie-Laure Yaspo,Benedikt Brors,Jörg Felsberg,Guido Reifenberger,V. Peter Collins,Nada Jabado,Roland Eils,Peter Lichter

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

2013

David T. W. Jones
Barbara Hutter
Natalie Jäger
Andrey Korshunov
Marcel Kool
Hans-Jörg Warnatz
Thomas Zichner
Sally R. Lambert
Marina Ryzhova
Dong Anh Khuong-Quang
Adam M. Fontebasso
Adrian M. Stütz
Sonja Hutter
Marc Zuckermann
Dominik Sturm
Jan Gronych
Bärbel Lasitschka
Sabine Schmidt
Huriye Seker-Cin
Hendrik Witt
Marc Sultan
Meryem Ralser
Paul A. Northcott
Volker Hovestadt
Sebastian Bender
Elke Pfaff
Sebastian Stark
Damien Faury
Jeremy Schwartzentruber
Jacek Majewski
Ursula D. Weber
Marc Zapatka
Benjamin Raeder
Matthias Schlesner
Catherine L. Worth
Cynthia C. Bartholomae
Christof von Kalle
Charles D. Imbusch
S. Radomski
Chris Lawerenz
Peter van Sluis
Jan Koster
Richard Volckmann
Rogier Versteeg
Hans Lehrach
Camelia-Maria Monoranu
Beate Winkler
Andreas Unterberg
Christel Herold Mende
Till Milde
Andreas E. Kulozik
Martin Ebinger
Martin U. Schuhmann
Yoon-Jae Cho
Scott L. Pomeroy
Andreas von Deimling
Olaf Witt
Michael D. Taylor
Stephan Wolf
Matthias A. Karajannis
Charles G. Eberhart
Wolfram Scheurlen
Martin Hasselblatt
Keith L. Ligon
Mark W. Kieran
Jan O. Korbel
Marie-Laure Yaspo
Benedikt Brors
Jörg Felsberg
Guido Reifenberger
V. Peter Collins
Nada Jabado
Roland Eils
Peter Lichter

Stefan Pfister and the ICGC PedBrain Tumor Project report whole-genome sequencing of 96 pilocytic astrocytomas. They identify recurrent activating mutations in FGFR1 and PTPN11 and novel NTRK2 fusion genes.

Keywords:

DNA sequencing
Genomics
Genetics
Fusion gene
Fibroblast growth factor receptor 1
Somatic cell
Molecular biology
Fibroblast growth factor
Biology
Pilocytic astrocytoma
PTPN11
Mutation
Childhood Glioblastoma
Gene
Astrocytoma
Disease

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