A Facile One-Pot Synthesis of Series of 2-Aminoquinoline-3-Carbonitrile Derivatives by Using Magnetite Nanoparticle Catalyst

2-Aminoquinoline-3-carbonitrile synthesized by one-pot condensation of aromatic 2-Choloro-3-Carboxyaldehyde, with aq. NH3, sublimed I2 and Fe2O3 nanoparticle catalyst. The C-N coupling reactions preceded much faster via simple SNAr displacement reactions of chlorine. The synthetic methods depended on functional group transformation, nucleophilic attack and/or intramolecular cyclization by the cyanoquinoline moiety. The competition of the reaction pathways including nucleophilic attack, and functional group transformation that leads to the synthesized product. This newly synthesized compound were characterized by elemental analysis and spectral data, and screened for their biological activity. The amination reactions using magnetite nanoparticle as catalyst gave the best yield of the products.