Resedronato: eficacia en la enfermedad de Paget. Experiencia del Hospital General Universitario y Hospital Universitario La Fe de Valencia

Paget's disease of bone is a frequent skeletal disease in our environment, only osteoporosis is more frequent; in Spain of older than 50 years are affected 1.5%. The incidence is around 65 years, and most of the cases diagnostic is casual in a patient who is asymptomatic without deformities and elevated alkaline phosphatase; so the patient is referred to rheumatologist. Biphosphonates and calcitonin has showed their therapeutic efficacy in Paget's disease of bone. We study efficacy of risedronate in Paget's disease of bone, so we review 18 patients treated with a course of risedronato 30 mg/day for 2 months; serum alkaline was monitored, before and at the end of treatment. Mean age was 60.1 years (50-79 years). Polyostotic manifestations were in 13 patients, and monostotic was in 5 patients. Degree of disease was moderate in 7 cases and was high in 11 patients. The treatment was effective in all the patients; 6 patients (40%) had partial effectiveness, 7 (40%) had good response and 5 (20%) had complete response. We consider risedronato an effective treatment to Paget's disease with easy administration and none adverse effects (no digestive intolerance was found).