Bone marrow vascular endothelial growth factor level per platelet count might be a significant predictor for the treatment outcomes of patients with diffuse large B-cell lymphomas

Objective: Developing a parameter to predict bonemarrow invasion by non-Hodgkin’s lymphoma is an important unmetmedical need for treatment decisions. This study aimed to confirm the validity of the hypothesis that bone marrow plasma vascular endothelial growth factor level might be correlated with the risk of bone marrow involvement and the prognosis of patients with diffuse large B-cell non-Hodgkin’s lymphoma. Methods: Forty-nine diffuse large B-cell lymphoma patients treated with rituximab, cyclophosphamide, daunorubicin, vincristine and prednisolone regimen were enrolled. Vascular endothelial growth factor level was measured with enzyme-linked immunosorbent assay. The validity of bone marrow plasma vascular endothelial growth factor level and bone marrow vascular endothelial growth factor level per platelet count for predicting treatment response and survival after initial rituximab, cyclophosphamide, daunorubicin, vincristine and prednisolone combined chemotherapy was assessed. Results: Bonemarrow plasma vascular endothelial growth factor level per platelet count was significantly associated with old age (≥65 years), poor performance score (≥2), high International prognosis index (≥3) and bone marrow invasion. The patients with high bone marrow plasma vascular endothelial growth factor level per platelet count (≥3.01) showed a significantly lower complete response rate than the others. On Kaplan–Meier survival curves, the patients with high bonemarrow plasma vascular endothelial growth factor levels (≥655 pg/ml) or high bonemarrow plasma vascular endothelial growth factor level per platelet count (≥3.01) demonstrated a significantly shorter overall survival and progression-free survival than the others. In the patients without bone marrow involvement, bone marrow plasma vascular endothelial growth factor level per platelet count had a significant relationship with overall survival and progression-free survival. Multivariate analysis revealed that the patients without BM invasion showing high level of bone marrow plasma vascular endothelial growth factor per platelet count had significantly shorter progression-free survival and overall survival. Japanese Journal of Clinical Oncology, 2015, 45(10) 914–920 doi: 10.1093/jjco/hyv102 Advance Access Publication Date: 16 July 2015 Original Article © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com 914 Conclusions: Bonemarrow plasma vascular endothelial growth factor level per platelet count might be associated with bone marrow invasion by diffuse large B-cell lymphoma and is correlated with clinical outcomes after treatment.