Tenascin-C Is a Possible Mediator Between Initial Brain Injury and Vasospasm-Related and -Unrelated Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

Introduction: Tenascin-C (TNC), a matricellular protein, exerts diverse functions, including tissue remodeling and apoptosis, and is induced in cerebrospinal fluid (CSF) after aneurysmal subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationships among CSF TNC levels, initial brain injury, delayed cerebral ischemia (DCI), and vasospasm after SAH.