Recurrent Stent Thrombosis Secondary to Immunoglobulin G4-Related Disease

Abstract Immunoglobulin G4-related disease (IgG4-RD) is an insidiously progressive multi-organ disease. However, lack of familiarity with IgG4-RD results in patients often being undiagnosed and under treated. IgG4-RD can affect any organ, and manifests as aortitis within the cardiovascular system. Cardiac involvement is less common, and myocardial infarction is rarely reported. We report the first case of a patient with multiple myocardial infarctions due to recurrent stent thrombosis associated with IgG4-RD, which resolved upon treatment of IgG4-RD. This case highlights the importance for cardiologists to consider IgG4-RD as a rare, but possible association with stent thrombosis.