Significance of IgG antibody detection of Aspergillus fumigatus in chronic pulmonary aspergillosis

Objective To examine the serum level of Aspergillus fumigatus IgG antibody and to explore its significance in chronic pulmonary aspergillosis (CPA), and to analyze the change of antibody titer before and after antifungal therapy, and to provide help for the early diagnosis, treatment and continuous monitoring of chronic pulmonary aspergillosis. Methods 42 cases of suspected patients were selected and the serum levels of Aspergillus fumigatus IgG antibody in serum were detected by enzyme-linked immunosorbent assay (ELISA) method, and the positive (>120 AU/ml) and suspicious positive (80~120 AU/ml) patients were rechecked after antifungal treatment, and the significance of the diagnosis and treatment effect evaluation was analyzed. Results Of the 42 cases of reexamination, 20 cases were positive and 6 cases were suspected positive, and the serum level of Aspergillus fumigatus IgG antibody was significantly higher in the serum.The clinical symptoms of 16 cases and 5 cases of suspected positive antifungal treatment were significantly reduced, and the overall IgG level of Aspergillus fumigatus decreased significantly, and the positive patient (>120 AU/ml) treatment was significantly decreased.The therapeutic effect was more significant. Conclusions The detection of Aspergillus fumigatus IgG antibody is of great significance in the early diagnosis of pulmonary aspergillosis, and the changes in serum level can be intuitively reacted positive patients (>120 AU/ml) for the prognosis of antifungal therapy. Key words: Aspergillus fumigatus; Immunoglobulin G; Pulmonary aspergillosis; Enzyme-linked immunosorbent assay; Antifungal agents