Lipid accumulation product is a reliable indicator for identifying metabolic syndrome: The China Multi-Ethnic Cohort (CMEC) Study.

BACKGROUND Previous studies have shown that lipid accumulation product (LAP) was associated with the risk of cardiometabolic disease, it is not clear whether LAP could be used as a marker to identify metabolic syndrome (MetS) among Chinese ethnic groups. AIM To assess the reliability of LAP as a maker to identify MetS among Dong adults. DESIGN Population-based cross-sectional study. METHODS We included 6,494 Dong individuals (1,403 patients) aged 30-79 years from southwest China. MetS was established by Chinese Diabetes Society. Logistic regression model was utilized to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Receiver operating characteristic (ROC) curve was utilized to calculate area under the ROC curve (AUC) and 95% CIs to obtain the identification ability for MetS. RESULTS The risk of MetS was increased with per 5 units increase of LAP (OR 1.37 [95% CI, 1.34-1.39]). Similar results were found in subgroup analyses and sensitivity analyses. Clustered metabolic risk associated with per 5 units increase of LAP was observed for people with 1 (OR 1.59 [95% CI, 1.53-1.65]), 2 (2.15 [2.06-2.24]), 3 (2.59 [2.48-2.71]), 4 (2.81 [2.69-2.95]), and 5 (3.03 [2.87-3.21]) MetS components. LAP presented higher AUC (0.915 [95% CI, 0.907-0.923]) than other included obesity indices (P < 0.05). CONCLUSIONS These data support evidence that LAP was related to the risk of MetS, had a high AUC, and could be a reliable index for identifying MetS patients among Dong adults in Chinese.