Generalized chloromas with multiple cranial nerves palsies in a patient with chronic myeloid leukemia in a tertiary institution in South-south Nigeria: A case report

Introduction: chloromas or granulocytic sarcomas are extramedullary granulocytic tumors which occur in acute myeloid leukemia (AML), myeloproliferative disorders and myelodysplastic syndromes. they are composed of myeloid blast and herald the onset of systemic relapse. case report: We report a rare case of 49-year-old male with generalized chloromas in chronic myeloid leukemia (cML) associated with multiple cranial nerves deficit suggesting an intracranial involvement. the central nervous system (cNs) is considered to be an uncommon site for chloromas. treatment with hydroxyurea was unremarkable as the chloroma became more widespread and neurological deficit worsen. this study brings to fore this rare presentation and the apparent limitation of hydroxyurea (cytoreductive therapy) in patient management. conclusion: Widespread florid chloromas presenting in chronic phase of cML with associated cNs manifestation is rare. the response to Initial therapy with hydroxyurea was unremarkable. the patient was discharged against medical advice and thus lost to followup.