P36: Clinical Features And Predictors Of Renal Disease In Juvenile Systemic Lupus Erythematosus

Objective : To describe renal involvement in Juvenile Systemic Lupus Erythematosus (JSLE) at presentation and during the course of disease; and assess for clinical predictors of renal disease. Methodology : A retrospective review of medical electronic records of all patients with JSLE seen at the paediatric rheumatology and nephrology units in Hospital Selayang from 2003-2009. Data collected included demographics, clinical and laboratory features. Results : There were 66 patients with JSLE (62 females, 4 males), with mean age at presentation of 9 years (3.9 - 13.4 years) and mean follow-up of 31.4 months (1-75 months). Majority (53.0%) were Malays, 42.4% Chinese and 4.5% Indians. 52 patients (78.8%) had renal involvement which was present in 35(67.3%) at presentation (group A) and another 17(32.7%) during follow-up (group B). Up to 42.8% (15/35) of Group A and 52.9% (9/17) of group B went into renal remission with treatment. Only 14/52(26.9%) had renal biopsies and the commonest patterns were Class IV Lupus Nephritis (6 patients) followed by Class III and Class II (3 patients each). Hypoalbuminemia at presentation had significant correlation with renal disease in these patients (p Conclusion : Majority of JSLE patients had renal involvement either at presentation or subsequently in the course of disease but no clinical predictors for the development of lupus nephritis could be identified in our cohort unlike other adult studies.