Abstract 9084: Selective Beta3-Adrenergic Receptor Antagonist Therapy Causes Regression of Cardiac Dysfunction in a Rat Model of Progressive Heart Failure: Insights into Molecular and Cellular Mechanisms

Xiaoqiang Sun,Che-Ping Cheng,Jing-Cao,Zhe Chen,Zhi Zhang,Tiankai Li,Xiaowei Zhang,David M. Herrington,David Zhao,Heng Cheng

Abstract 9084: Selective Beta3-Adrenergic Receptor Antagonist Therapy Causes Regression of Cardiac Dysfunction in a Rat Model of Progressive Heart Failure: Insights into Molecular and Cellular Mechanisms

2021

Xiaoqiang Sun
Che-Ping Cheng
Jing-Cao
Zhe Chen
Zhi Zhang
Tiankai Li
Xiaowei Zhang
David M. Herrington
David Zhao
Heng Cheng

Background: Heart failure (CHF) causes cardiac β3-adrenergic receptor (AR) upregulation with resultant enhanced β3-AR-stimulated-Gi-coupled negative modulation on cardiac function. This suggests a ...

Keywords:

Downregulation and upregulation
Medicine
Antagonist
Cardiology
Heart failure
Cardiac function curve
Adrenergic receptor
Beta blocker
Receptor
Internal medicine
Hemodynamics

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