Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans

A. Monroy,S. Kamath,A. O. Chavez,Victoria E. Centonze,M. Veerasamy,A. Barrentine,J. J. Wewer,Dawn K. Coletta,Christopher P. Jenkinson,R. M. Jhingan,D. Smokler,Sara M. Reyna,Nicolas Musi,R. Khokka,Massimo Federici,Devjit Tripathy,Ralph A. DeFronzo,Franco Folli

Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans

2009

A. Monroy
S. Kamath
A. O. Chavez
Victoria E. Centonze
M. Veerasamy
A. Barrentine
J. J. Wewer
Dawn K. Coletta
Christopher P. Jenkinson
R. M. Jhingan
D. Smokler
Sara M. Reyna
Nicolas Musi
R. Khokka
Massimo Federici
Devjit Tripathy
Ralph A. DeFronzo
Franco Folli

Aims/hypothesis TNF-α levels are increased in obesity and type 2 diabetes. The regulation of TNF-α converting enzyme (TACE) and its inhibitor, tissue inhibitor of metalloproteinase 3 (TIMP3), in human type 2 diabetes is unknown.

Keywords:

Insulin
Insulin resistance
Matrix metalloproteinase
Tissue inhibitor of metalloproteinase
Skeletal muscle
Enzyme inhibitor
Endocrinology
Type 2 diabetes
Diabetes mellitus
Internal medicine
Biology

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