Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding
2003
Rationale and Objectives:GdDOTP5− is a highly charged, bone-seeking paramagnetic complex that could potentially detect bone lesions by magnetic resonance imaging (MRI). To date, its pharmacokinetics, effects on organ relaxivity, and interaction with hydroxyapatite (HA) has not been described.Methods
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