Effects of BPC on cadmium-induced lesions in rats and mice

BPC(Body Protection Compound) is newly isolated peptide with considerable organoprocetive effect on various experimentally induced lesions. Parenteral administration of cadmium induces testicular atrophy, renal dysfunction, hypertension, hepatic and CNS injury and peritonitis. Animals (rats and mice) werw treated with cadmium (400 mg/kg b.w.i.p.)five times, every 12 hours. BPC was applied as pretreatment (1 hour before) or posttreatmant (once a day over 7 or 14 days) 10 micrograms/kg i.p.. The volume and cellular content of peritoneal exudate was estameted as well as pathological change liver, spleen and parietal peritoneum. In both BPC-treatedgroups the exudate volume and number of cell was significantly decreased as compared to saline-treated controls. The cadmium-induced pathohistological change include severe midzonal and periportal necrosis of hepatocytes with hepatocellular jaundice, spleen haemorrhage and congestion and mixtocellular peritonitis with myositis and hyaline degeneration of abdominal muscles. BPC-pretreated animals had no signs of hepatocellular necrosis, spleen haemorrhage were significantly lesser degree. The postexposure treatmant with BPC had also a beneficial effect on pathohistological changes.