Towards a Framework for Evaluating and Reporting Hansen Solubility Parameters: Applications to Nano and Micron Scale Particle Dispersions
2021
A thorough understanding of complex
interactions within particulate systems is a key for knowledge-based
formulations. Hansen solubility parameters (HSP) are widely used to assess the
compatibility of the dispersed phase with the continuous phase. At present, the
determination of HSP is often based on a liquid ranking list obtained by
evaluating a pertinent dispersion parameter using only one pre-selected characterization
method. Furthermore, one cannot rule out the possibility of subjective judgment
especially for liquids for which it is difficult to decipher the compatibility
or underlying interactions. As a result, the end value of HSP might be of
little or no information. To overcome these issues, we introduce a generalized
technology-agnostic combinatorics-based approach. We discuss the principles of
the approach and the implications of evaluating and reporting particle HSP
values. We demonstrate the approach by using SiNx particles synthesized in the gas phase. We
leverage the analytical centrifugation data to evaluate stability trajectories
of SiNx dispersions in various liquids to deduce particle-liquid
compatibility.
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