The effect of comorbidity on stage-specific survival in resected non-small cell lung cancer patients.

7026 Background: TNM classification has been the traditional cornerstone of decision-making in treatment choices of lung cancer. In addition to TNM stage and lung function, there is no other objective information to support this decision. Severe comorbidity affects overall survival, and may be an independent prognostic factor. In this study we quantified the effect of comorbidity on stage-specific survival in resected non-small cell lung cancer (NSCLC) patients in a large population-based setting. Methods: Among 3,152 NSCLC patients from the Danish Lung Cancer Registry who underwent surgical resection between 1 January 2005 and 31 December 2010, mortality hazard ratios were calculated during three consecutive time periods following surgery (0-1 month, 1 month - 1 year and >1 year) according to Charlson comorbidity score (CCS 0, 1-2, 3+), ECOG performance status, lung function, age, sex, pathological T and N stage according to the revised 7th edition TNM lung cancer staging system, using Cox proportional h...