Motion degradation in optic nerve MRI: A randomized intraindividual comparison study of eye states.

Abstract Purpose MRI is a powerful tool for optic nerve assessment, but image quality can be degraded by artifacts related to ocular motion. The purpose of this investigation was to evaluate the effect of undergoing MRI with eyes open versus closed on the degree of motion degradation affecting the optic nerves. Method Patients undergoing 3 Tesla orbital MRI were randomized to undergo the coronal STIR sequence with eyes open and focused on a standardized fixation point, blinking as needed, or with eyes closed. The sequence was then performed again with the other instruction set. Two neuroradiologists rated the intraorbital optic nerves for motion artifact on a 5-point scale (higher numbers reflecting greater motion artifact) in 2 locations of each nerve. Differences were evaluated by the clustered Wilcoxon signed rank test. Results Seventy-seven orbits were included. Interrater reliability was high (weighted kappa = 0.78). The anterior intraorbital optic nerves were rated with less motion artifact when eyes were open and focused during acquisition than when closed (p = 0.006), but this was not the case for the posterior intraorbital optic nerve (p = 0.69). For example, at the anterior intraorbital optic nerve, motion artifact of mean grade better than 2 was seen in 60% of eyes-open vs. 32% of eyes-closed acquisitions, while mean grade 4 or worse was seen in 4% of eyes-open vs. 12% of eyes-closed acquisitions. Conclusion Undergoing orbital MRI with eyes open and focused rather than closed reduces motion artifact at the anterior intraorbital segment of the optic nerve.