Poly(ADP-Ribose) Transferase in Lizard Oviduct

Poly(ADP-ribose) transferase often undergoes a drastic change in its activity following the action of various biological effectors in a variety of cell systems or tissues. An increase in poly(ADP-ribose) transferase activity was usually observed in those systems in which the biological effectors were followed with cell proliferation, for instance, in immature quail oviduct after estrogen treatment (1). On the contrary, a drastic decrease in poly(ADP-ribose) transferase activity was often detected in a number of cells after treatment with effectors used to induce an arrest of cell proliferation such as interferons (2) and retinoic acid (3). Virus gene expression of mouse mammary tumor induced after glucocorticoid treatment seems to be strictly correlated with a marked decrease in poly(ADP-ribosyl)ation of HMG 14 and 17 in pituitary gland cells (4).